Injectable Hydrogel Systems

Injectable Hydrogel Systems

A lot of our work focuses on developing injectable biomaterial systems. They are highly attractive for disc repair as they: Provide cell protection during intradiscal delivery; Prevent cell leakage; Better distribution, avoid “cell clumping”; Provides a protective/instructive niche (cell anchorage/differentiation); Facilitate advanced strategies (e.g. growth factors/agents/gene delivery)

Self Healing Hydrogel Systems

These are a branch of hydrogel systems which can undergo “self-healing” or repair. Networks through dynamic Schiff-base- continuous breaking and regenerating resulting in injectable and self-healing properties

Injectable microcapsules and microcarriers

Recent work in our lab has focused on developing injectable microcapsules and microcarriers that can be primed in vitro using growth factors

Naqvi S.M., Vedicherla S.V., Gansau J,  McIntyre T, Doherty M and Buckley C.T. “Living Cell Factories”- Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery. Advanced Materials, 28(27):5662-71, 2016.

Macroscopic images of  healthy, untreated, unprimed and primed microencapsulated BMSC-treated bovine discs after 28 d of whole organ culture demonstrating tissue regeneration 

Naqvi S.M., Gansau J., Gibbons, D.L. and Buckley C.T. Primed and cryopreserved stem cell microcapsules for IVD regeneration - in vitro co-culture and ex vivo organ culture assessment. eCM 37: 134-152, 2019